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Article from: Genetics
Article date: November 01, 2008
Author: Rosset, Saharon; Wells, R Spencer; Soria-Hernanz, David F; Tyler-Smith, Chris; Royyuru, Ajay K; Behar, Doron M
ABSTRACT
The mitochondrial DNA hypervariable segment I (HVS-I) is widely used in studies of human evolutionary genetics, and therefore accurate estimates of mutation rates among nucleotide sites in this region are essential. We have developed a novel maximum-likelihood methodology for esti
mating site-specific mutation rates from partial phylogenetic information, such as haplogroup association. The resulting estimation problem is a generalized linear model,with a nonstandard link function. We develop inference and bias correction tools for our estimates and a hypothesis-testing approach for ...
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