WASHINGTON (AP) — The Republicans' capstone health care overhaul seemed in dire trouble Friday as Speaker Paul Ryan weighed strategy at the White House with President Donald Trump. GOP lawmakers and aides said they lacked the votes to succeed in the House, just hours before a do-or-die showdown demanded by Trump.

GOP leaders pushed toward a climactic House roll call, but their promise to stage the vote increasingly looked like a losing gamble for the new president and his GOP allies in Congress.

Vice President Mike Pence was meeting near the Capitol with the House Freedom Caucus. That group's hard-right members, along with a growing band of party moderates, have been driving GOP opposition and threatening to crash one of Trump's and Ryan's top priorities.

"I think the president has given it his all," White House spokesman Sean Spicer told reporters in what sounded like a concession that the measure's fate was bleak. He added, "The speaker has done everything he can. You can't force people to vote."

Three more GOP moderates publicly declared their opposition: Reps. Barbara Comstock of Virginia, David Joyce of Ohio and Rodney Frelinghuysen of New Jersey, chairman of the House Appropriations Committee.

Those announcements contrasted with no visible signs that leaders had the support they'd need to avoid a damaging defeat.

White House officials told rank-and-file Republicans late Thursday that the president was through negotiating with holdouts. White House officials said that if the measure failed, Trump would move to the rest of his agenda — leaving lawmakers to blame for blocking the party's long-time goal of overturning Obama's overhaul.

"We'll see what happens," Trump said Friday when asked his course should the measure fail.

The GOP bill would eliminate the Obama statute's unpopular fines on those who do not obtain coverage and the often generous subsidies for those who purchase insurance. Instead, consumers would face a 30 percent premium penalty if they let coverage lapse.

Republican tax credits would be based on age, not income like Obama's subsidies, and tax boosts Obama imposed on higher-earning people and health care companies would be repealed. The bill would end Obama's Medicaid expansion and trim future federal financing for the federal-state program, let states impose work requirements on some of its 70 million beneficiaries.

In a morning tweet, Trump targeted the Freedom Caucus. The bill would replace major parts of Obama's law and block federal payments for a year to Planned Parenthood.

"The irony is that the Freedom Caucus, which is very pro-life and against Planned Parenthood, allows P.P. to continue if they stop this plan!" Trump wrote.

For Trump, victory would clear an initial but crucial hurdle toward achieving the GOP's lodestar quest to repeal "Obamacare," the former president's 2010 health care overhaul. Defeat could weaken Trump's political potency by adding a legislative failure to a resume already saddled with inquiries into his campaign's Russia connections and his unfounded wiretapping allegations against Obama.

The nonpartisan Congressional Budget Office has said the Republican bill would result in 24 million additional uninsured people in a decade and lead to higher out-of-pocket medical costs for many lower-income and people just shy of age 65, when they become eligible for Medicare.

Obama's law increased coverage through subsidized private insurance for people without workplace coverage, and letting states expand Medicaid for low-income residents. More than 20 million people have gained coverage since the law was passed.

Democrats were uniformly against the GOP drive to roll back one of Obama's legacy achievements.

"This bill is pure greed, and real people will suffer and die from it," said Rep. Pramila Jayapal of Washington state.

In Friday's first meaningful roll call, the House used a near party-line 230-194 vote to approve changes that leaders hoped would win over unhappy Republicans. These included improving Medicaid benefits for some older and disabled people and abolishing Obama's requirements that insurers cover specific services like maternity care.

House leaders seemed to be calculating that at crunch time enough dissidents will decide against sabotaging the bill, Trump's young presidency and the House GOP leadership's ability to set the agenda..

Republicans can lose only 22 votes in the face of united Democratic opposition. A tally by The Associated Press found at least 32 "no" votes, but the figure was subject to fluctuation amid frantic GOP lobbying.

GOP aides were privately saying conservative opposition was softening, yet another moderate announced he would oppose the legislation. Rep. Rodney Frelinghuysen, of New Jersey, chairman of the House Appropriations Committee, said the bill "would place significant new costs and barriers to care on my constituents."

For one opponent, Rep. Paul Gosar, R-Ariz., Trump's declaration that Friday was the GOP's last shot at repealing Obama's statute seemed to inspire only defiance.

"We're the legislative body last I looked, not the president," Gosar said.

Other Republicans said it was time for party loyalty.

"Too many people on our team feel like we have team members that are not, they're deserting us," said Rep. Chris Collins, R-N.Y., an early Trump supporter. "And in some cases for self-preservation. When someone says I have to vote no or I won't be re-elected, I don't respect that."

Republicans still face an uphill climb in the Senate, where conservatives and moderates are threatening to sink it.

In an embarrassing setback, leaders abruptly postponed the vote Thursday because a rebellion by conservatives and moderates would have doomed the measure.

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Associated Press writers Matthew Daly, Kevin Freking, Mary Clare Jalonick, Richard Lardner, Stephen Ohlemacher, Vivian Salama, Ken Thomas and Erica Werner contributed to this report.