MILWAUKEE (AP) — Josh Harrison homered, doubled, singled and drove in a career-high five runs, leading the Pittsburgh Pirates over the Milwaukee Brewers 8-3 Friday night.

Andrew McCutchen also homered for Pittsburgh, which had lost nine of 12 going into the series against the NL Central-leading Brewers.

Jeff Locke (5-3) pitched six strong innings, giving up two runs and two hits. He walked six, but was able to strand five runners.

Yovani Gallardo (8-7) lasted just five innings, allowing six runs on eight hits and three walks.

Ryan Braun's two-run homer in the first inning gave Milwaukee a 2-0 lead. It was his 16th home run of the season, but just his second since July 22 as he's been slowed by a sore thumb.

Pittsburgh came right back in the second for 3-2 lead, taking advantage of Gallardo's wildness as he issued two straight walk after an error by third baseman Aramis Ramirez. Jody Mercer hit a sacrifice fly and Harrison lined a two-run double.

The Pirates made it 4-2 on Neil Walker's RBI triple in the third and Harrison singled home a run in the fourth.

McCutchen hit his 18th home run of the season leading off the fifth. It was his third game since coming off the disabled list because of a rib fracture and it was his first home run since he hit two against Cincinnati on July 12.

Harrison hit a two-run homer in the eighth.

TRAINER'S ROOM:

Pirates: Manager Clint Hurdle expressed cautious optimism that INF Clint Barmes would be able to rejoin the team during a three-game series with St. Louis that starts Monday. Barmes has been out since early July with a left groin strain and is currently on a rehab assignment with Triple-A Indianapolis.

Brewers: RHP Kyle Lohse, who missed his last start due to a sore right ankle, is set to start Monday against the San Diego Padres. Lohse threw a bullpen session Friday and said afterward he felt good. ... RHP Matt Garza (left oblique strain) will throw a bullpen session Sunday. Manager Ron Roenicke said he hopes Garza would return to the starting rotation in early September.

ON DECK

Pirates: RHP Edinson Volquez (10-7) starts Saturday at Miller Park. He has won six of this last seven decisions.

Brewers: RHP Wily Peralta (15-7), tied for the major league lead in wins, faces the Pirates.