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Doctors Seek to Replicate This Man's 'HIV Cure'

'Berlin Patient' Timothy Ray Brown remains HIV-negative

By Rob Quinn,  Newser Staff

Posted May 17, 2011 2:40 AM CDT

(Newser) – Six months after his case attracted worldwide attention, "Berlin Patient" Timothy Ray Brown appears to still be the first person ever to have been cured of HIV. The virus was eliminated from Brown's body after he received a bone marrow stem cell transplant while being treated for leukemia. "I’m cured of HIV. I had HIV but I don’t anymore," Brown tells CBS5 in San Francisco, where amazed experts are monitoring his progress. Doctors believe Brown received stem cells from a donor who was among the 1% or so of the Caucasian population that is immune to HIV.

Stem cell researchers are now trying to replicate the same results. Experts say that while the radical treatment that appears to have cured Brown carries many risks, talk of a cure for AIDS no longer seems premature. "If you’re able to take the white cells from someone and manipulate them so they’re no longer infected, no longer infectable by HIV, and those white cells become the whole immune system of that individual, you’ve got essentially a functional cure," explains researcher Jay Levy, who co-discovered the HIV virus.

I quit taking my HIV medication the day that I got the transplant and haven’t had to take any since, Brown says.
"I quit taking my HIV medication the day that I got the transplant and haven’t had to take any since," Brown says.   (YouTube)
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COMMENTS
Showing 3 of 18 comments
djnross@yahoo.com
Jul 3, 2011 9:12 AM CDT
HIV-immunity,such as it is,has a natural history the knowledge of which makes it fairly easy to deduce why this patient successfully purged AIDS.It has to do with the serologic condition of his donor,obviously one of the rarer European descendents of those who passed on---via chromosome 3p21---an heterozygous copy of the CCR5-delta32 gene which chemokine-receptor activity resists T-cell invasion of HIV altogether.It came from a deletion/Founder mutation Natural selection endowed certain European alleles with during the Black Death.5 to 13% of Northern European people possess 2 copies of the homozygous version that has deleted a 32 bp segment.These persons possess limited immunity to both smallpox and AIDS.But those with the single heterozygous copy----about 1% of the Caucasian population----have complete immunity.
positiveguy
May 18, 2011 2:28 AM CDT
There are 33,300,000 of HIV positive single people worldwide. If you are one of them and you are prepared to become a little brave then You may find that POZmingle. com is just for you. For you will come across new individuals who will certainly become life long friends or Love of life and achieve a degree of self-belief you never would have believed possible. 
finkster
May 17, 2011 10:12 PM CDT
Great!!!....maybe they can do some "smart cell transplants" for the dummies out there.
 

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