America's Richest, Poorest Cities San Jose is No. 1 in terms of income; poorest is Detroit By Matt Cantor, Newser User Posted Sep 21, 2012 11:26 AM CDT Updated Sep 21, 2012 11:45 AM CDT 20 comments Comments Downtown San Jose. (Shutterstock) (Newser) – Of the country's 25 most populated cities, San Jose has the highest median household income: near $77,000, compared to the national median of $51,000. San Jose's success is thanks in part to its high-tech culture. MarketWatch lists the five richest, with median incomes: San Jose, $77,000 San Francisco: $70,000 Washington, DC: $63,000 Seattle: $61,000 San Diego: $61,000 On the flip side is Detroit, with a $25,000 median income—the lowest of the 25 cities. Just 13% of its residents age 25 and up have college degrees; the national figure is 29%. The bottom five: Detroit, $25,000 Philadelphia: $34,000 Memphis: $35,000 Baltimore: $39,000 Indianapolis: $39,000 Click for the full list.