Youngest Recipient of Bioengineered Organ Dies

Hannah Warren had a windpipe implanted in April

By Evann Gastaldo,  Newser Staff

Posted Jul 8, 2013 8:20 AM CDT

(Newser) – Hannah Warren, the youngest person ever to have had a bioengineered organ implanted, died Saturday, the New York Times reports. She was just two years old. Hannah was born without a trachea, and had a bioengineered windpipe implanted in April. Her esophagus was also involved in that surgery, and she had a second operation last month when it didn't heal correctly; complications from that operation ultimately killed her. "The trachea was never a problem," explains the surgeon. "It was her native tissue that was very fragile."

Stem cells from the toddler's bone marrow were attached to the plastic windpipe; they multiplied to create the trachea, the Telegram explains. The FDA approved the experimental surgery, which had been performed just five times previously and never in the US, because the little girl had small chance of surviving without it. "Hannah was a pioneer," says another surgeon. "At this point, we’re all just raw with pain." The longest person to have survived after a similar windpipe surgery has lived more than two and a half years post-surgery so far.

Darryl Warren and Lee Young-mi visit daughter Hannah in a post-op room at Children's Hospital of Illinois in Peoria after she received a new windpipe in a landmark transplant operation April 9, 2013.   (AP Photo/Courtesy of OSF Saint Francis Medical Center, Jim Carlson)
In this July 13, 2012 photo, Hannah Warren, 2, poses with her parents Lee Young-mi and Darryl Warren at Seoul National University Hospital in Seoul, South Korea.   (AP Photo/The Korea Herald, Kim Myung-sub)
Hannah Warren, 2, lies in bed in a post-op room at the Children's Hospital of Illinois in Peoria, after having received a new windpipe in a landmark transplant operation on April 9, 2013.   (AP Photo/OSF Saint Francis Medical Center, Jim Carlson)
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