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Docs ID Prostate Cancer Gene Markers

Screening test for men at risk could be on market in 3 years

By Katherine Thompson,  Newser Staff

Posted Feb 11, 2008 12:00 PM CST

(Newser) – Seven genetic markers that increase a man's risk of developing prostate cancer have been identified, the Guardian reports. A test to screen for the affected genes should be ready within 3 years, British researchers say, leading to more effective early diagnosis and treatment of the disease. The newly identified genes, each of which raises the risk of prostate cancer by around 60%, may lead to new drug therapies.

Current screening done regularly in the US for men over 50 relies on family history and the prostate-specific antigen (PSA) blood test, which Britain doesn't consider reliable enough to implement widely. "We are entering an era of very exciting medicine. This kind of genetic medicine will definitely happen and I definitely think it will deliver," said the lead doctor on the study.

Before genetic tests were available, early diagnosis was more difficult. Here, a Prostate 3.0 Tesla MRI Image shows the Region of Interest (ROI) localizing the patient's disease.  A subsequent biopsy was used to confirm cancer.  (PRNewsFoto/Diagnostic Center) for Disease)
Before genetic tests were available, early diagnosis was more difficult. Here, a Prostate 3.0 Tesla MRI Image shows the Region of Interest (ROI) localizing the patient's disease. A subsequent biopsy...   (Associated Press)
PROSTASCINT is the first and only commercial monoclonal antibody-based agent targeting prostate-specific membrane antigen (PSMA) to image the extent and spread of prostate cancer. Such a test was used to help callibrate studies looking for genetic red flags of prostate cancer risk.
PROSTASCINT is the first and only commercial monoclonal antibody-based agent targeting prostate-specific membrane antigen (PSMA) to image the extent and spread of prostate cancer. Such a test was used...   (Associated Press)
Former Kansas Sen. Bob Dole, left, points to a poster of a new postal stamp promoting  prostate cancer awareness during the National Men's Health and Fitness Conference in Philadelphia in this June 3, 1999 file photo. Dole was diagnosed with prostate cancer in 1990.   (AP Photo/Chris Gardner, File)
Former Kansas Sen. Bob Dole, left, points to a poster of a new postal stamp promoting prostate cancer awareness during the National Men's Health and Fitness Conference in Philadelphia in this June 3,...   (Associated Press)
A cryosurgery team, at Froedtert Memorial Lutheran Hospital in Milwaukee, Wisconsin, monitors a prostate cancer procedure on an ultrasound screen. Researchers hope that better advanced detection techniques will improve the prognosis of many patients.
A cryosurgery team, at Froedtert Memorial Lutheran Hospital in Milwaukee, Wisconsin, monitors a prostate cancer procedure on an ultrasound screen. Researchers hope that better advanced detection techniques...   (KRT Photos)
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