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Antidepressants Mostly Useless, Study Finds

Prozac and others make a difference only in most extreme cases

By Zach Samalin,  Newser Staff

Posted Feb 26, 2008 7:41 AM CST

(Newser) – Big Pharma swallowed a bitter pill yesterday as Prozac and other antidepressants were found in a UK study to be largely ineffectual in all but the most extreme cases of depression. The meta-analysis of 47 clinical trials submitted to the FDA with licensing applications for six popular antidepressants concluded that they should be prescribed only when all other treatments fail to yield results, the Independent reports.

"This study raises serious issues that need to be addressed surrounding drug licensing and how drug trial data is reported," one researcher said. The pharmaceutical industry has remained calm about the latest findings. "This one study should not be used to cause unnecessary alarm for patients," GlaxoSmithKline announced. But doctors are expected to be "much more cautious about prescribing" antidepressants, one author said.

Wyeth's headquarters in Madison, N.J., is seen in a file photo from April 28, 2004. The drugmaker's market exclusivity for Effexor _ its top-selling antidepressant drug _ is being threatened by Sun Pharmaceutical Industries Ltd., a generics manufacturer in India. (AP Photo/Daniel Hulshizer, File)
Wyeth's headquarters in Madison, N.J., is seen in a file photo from April 28, 2004. The drugmaker's market exclusivity for Effexor _ its top-selling antidepressant drug _ is being threatened by Sun Pharmaceutical...   (Associated Press)
Two bottles of Prozac are seen on a pharmacy shelf January 4, 2005 in New York City.
Two bottles of Prozac are seen on a pharmacy shelf January 4, 2005 in New York City.   (Getty Images)
A bottle of Prozac is pictured at a Eli Lilly and Co facility in Plainfield, Ind., Friday, Jan. 11, 2008. (AP Photo/Darron Cummings)
A bottle of Prozac is pictured at a Eli Lilly and Co facility in Plainfield, Ind., Friday, Jan. 11, 2008. (AP Photo/Darron Cummings)   (Associated Press)
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