The 10 Fattest Cities in the US Don't blame the South, its food is just too good By Michael Harthorne, Newser Staff Posted Mar 23, 2016 12:32 PM CDT 112 comments Comments Melted cheese is poured over pulled pork and chips for BBQ nachos in Memphis, Tennessee–the US' fattest city. (Mark Weber/The Commercial Appeal via AP) (Newser) – Obesity-related medical treatments cost Americans up to $315.8 billion every year, and that could increase by up to $66 billion per year if current health trends continue. With the increasing cost of the US' obesity epidemic in mind, WalletHub looked at the 100 largest American cities (by population, not weight) and ranked them by fatness. To get the rankings, the website looked at obesity rates, what residents are eating, the activity levels of residents, and more. Here are the 10 fattest cities: Memphis, Tenn. Shreveport-Bossier City, La. Indianapolis-Carmel-Anderson, Ind. Jackson, Miss. New Orleans-Metairie, La. Chattanooga, Tenn. Mobile, Ala. San Antonio-New Braunfels, Texas Greenville-Anderson-Mauldin, SC Little Rock-North Little Rock-Conway, Ark. See the full rankings here.