6 States With Most Mental Illness West Virginians especially struggle with it By Jenn Gidman, Newser Staff Posted Apr 25, 2016 11:52 AM CDT Updated Apr 30, 2016 3:40 PM CDT 102 comments Comments West Virginia is struggling with this issue the most. (Shutterstock) (Newser) – Nearly 10 million Americans experience a serious mental illness within any one year, and 24/7 Wall St. outlines the 12 states that have the largest adult populations struggling with various forms of mental illness, including depression and bipolar disorder. To come up with this ranking, the site examined surveys administered between 2013 and 2014 by the Substance Abuse and Mental Health Services Administration. The reviewers also looked at per capita drug prescription rates, poverty rates, education, and mental health legislation, among other factors, to round out its analysis. Here, the six states dealing the most with this issue: West Virginia; 5.4% of adults said to have serious mental illness Vermont; 5.3% Maine; 5.2% Arkansas; 5.1% Kentucky; 4.9% Missouri; 4.9% See all 12 states here.