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Scientists Discover New Diabetes Genes

Six variants each add risk for developing the disease

By Katherine Thompson,  Newser Staff

Posted Mar 31, 2008 9:40 AM CDT
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(Newser) – Scientists pooling data from European and US studies have identified six more genes associated with a higher risk of type 2 diabetes, the Guardian reports. The study, published in Nature Genetics, found small but significant connections between the genes and the disease, with certain genetic variants linked to a 10-15% increase in risk. Researchers hope the discovery can lead to developments in prevention and treatment.

Scientists don't know why these genes affect diabetes rates, but suspect they may influence cells' ability to overcome insulin resistance. In type 2 diabetes, the body does not respond properly to insulin produced by beta cells in the pancreas. "One of the most exciting bits is that we're finding lots of unexpected connections," said a researcher, who noted that one of the six genes has also been linked to prostate cancer.

Top worldwide diabetic populations, percentage of diabetes types and types of treatment used.
Top worldwide diabetic populations, percentage of diabetes types and types of treatment used.   (Associated Press)
Scientists have identified six new genes that each raise the risk of contracting type 2 diabetes by 10-15%.
Scientists have identified six new genes that each raise the risk of contracting type 2 diabetes by 10-15%.   (Shutterstock)
Participants in the Step Up to Fight Diabetes campaign charge up the famous Philadelphia Museum of Art steps in preparation for their 10- mile, 25 staircase walk.
Participants in the Step Up to Fight Diabetes campaign charge up the famous Philadelphia Museum of Art steps in preparation for their 10- mile, 25 staircase walk.   (Associated Press)
Scientists have found six new gene variants that raise the risk of Type 2 diabetes. In one of the largest studies of human genetic variability, the scientists tested more than 90,000 people.
Scientists have found six new gene variants that raise the risk of Type 2 diabetes. In one of the largest studies of human genetic variability, the scientists tested more than 90,000 people.   (Associated Press)
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Hope is that findings can lead to prevention, treatment
Reuters

Genes may trade one illness for another
Times (UK)

Letter abstract of study
Nature

Genes Also Illuminate Colon Cancer

Next step is diagnostic test for genetic markers
AFP

Bowel cancer genes affect only some races
BBC

 
medical breakthrough • prostate cancer • diabetes • genetic testing • genes • Oxford University • genetic research • type 2 diabetes • Nature Genetics

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