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Scientists Reprogram Adult Cells

Breakthrough could leap embryonic stem-cell quagmire

By Jess Kilby,  Newser User

Posted Aug 28, 2008 2:20 AM CDT

(Newser) – In a stunning medical advance, scientists have found a way to transform an adult cell in a living animal into an entirely different type of cell. The development is another step toward freeing the field of regenerative medicine from the controversies of stem-cell research. Harvard biologists discovered three key molecular switches that converted common pancreatic cells in mice into insulin-producing ones that diabetics need, reports the Washington Post.

"One day, this may allow the doctor to replace the scalpel with a sort of genetic surgery," said a researcher, who called such an advance a “holy grail” of medicine. Several experts say stem-cell research that relies on human embryonic cells will continue to be important, but a critic of the practice hailed the breakthrough as a “win-win situation for medicine and ethics.”

Harvard researchers have discovered a way to convert an adult cell within a living animal into an entirely different type of cell, reports the journal Nature.
Harvard researchers have discovered a way to convert an adult cell within a living animal into an entirely different type of cell, reports the journal Nature.   (Index Open)
Researchers converted common pancreas cells in diabetic mice into insulin-producing cells that enable the animals to regulate their own blood-sugar levels.
Researchers converted common pancreas cells in diabetic mice into insulin-producing cells that enable the animals to regulate their own blood-sugar levels.   (Index Open)
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It's kind of an extreme makeover of a cell. The goal is to create cells that are missing or defective in people. It's very exciting. - Douglas A. Melton, co-director of the Harvard Stem Cell Institute, who led the research

I see no moral problem in this basic technique. This is a 'win-win' situation for medicine and ethics. - Richard Doerflinger of the U.S. Conference of Catholic Bishops, a leading opponent of embryonic stems cell research

I'm stunned. It introduces a whole new paradigm for treating disease. - Robert Lanza, chief scientific officer of Advanced Cell Technology in Worcester, Mass., a developer of stem cell therapies

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