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Genetic Hiccup Causes Obesity In Mice: Study

Evolutionary relic in humans could be fixed by drug or gene therapy

By Harry Kimball,  Newser Staff

Posted Oct 2, 2008 5:07 PM CDT

(Newser) – Scientists have discovered an immune system pathway in the brain that they think is the root cause of diseases related to obesity, Reuters reports. When mice were overfed, the hypothalamus secreted a compound that suppressed the conversion of food into energy, and led to inflammation associated with heart disease and diabetes. Altering the gene responsible through genetic engineering kept the mice slim and healthy.

A lead author of the study thought the actions of the hypothalamus were adaptations tailored to an earlier time in evolution, when food was scarce. Today, “this pathway is mobilized by a different environmental challenge—overnutrition.” Though genetic engineering in humans isn't an option, drugs or gene therapy might someday suppress the hypothalamus’ outdated activity.

A nurse coordinator of Stanford's bariatric program, talks about research on weight loss at Stanford Hospital in Palo Alto, Calif.
A nurse coordinator of Stanford's bariatric program, talks about research on weight loss at Stanford Hospital in Palo Alto, Calif.   (AP Photo)
Diabetes is one of a number of diseases associated with obesity.
Diabetes is one of a number of diseases associated with obesity.   (AP Photo)
Deep-fried goodies.
Deep-fried goodies.   (AP Photo)
A new study may shed greater light on why overeating causes a wide range of diseases.
A new study may shed greater light on why overeating causes a wide range of diseases.   (AP Photo)
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