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Amish Gene May Help Protect Heart

Missing gene could keep triglycerides low

By Harry Kimball,  Newser Staff

Posted Dec 12, 2008 4:41 PM CST
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(Newser) – About 5% of Pennsylvania Amish have a rare genetic mutation that makes them less susceptible to cardiovascular disease, Reuters reports. A new study shows that the 5% lack a second copy of a gene that inhibits the breakdown of harmful fats, or triglycerides, in the bloodstream that can harden and narrow arteries. Researchers hope to develop targeted drugs from the study.

“The Old Order Amish are ideal for genetic research because they are a genetically homogenous people who trace their ancestry back 14 generations,” one of the researchers said. They also think the mutation, which is thought to be absent or extremely rare in the rest of the population, sprung from one person in the 18th century.

An Amish farmer rakes hay.
An Amish farmer rakes hay.   (AP Photo)
With the help of their two work horses, Amish farmers bring in straw at a farm in Burton, Ohio.
With the help of their two work horses, Amish farmers bring in straw at a farm in Burton, Ohio.   (AP Photo)
Three young Amish women walk.
Three young Amish women walk.   (AP Photo)
Four Amish children ride in a small wagon to a luncheon.
Four Amish children ride in a small wagon to a luncheon.   (AP Photo)
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People who have the mutation all have low triglycerides. This gives us clues that ultimately could develop future treatments. - Toni Pollin, University of Maryland School of Medicine

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COMMENTS
Showing 1 of 1 comment
Shannonals
Dec 27, 2008 2:33 AM CST
This isn't sa hard to understand, it's not as if the Amish are involved in worldy affairs and/or bad habits.

Amish intermarriage also exacerbates rate of rare disease
CBS News

Another look at the research
Telegraph (UK)

 
heart disease • Pennsylvania • genetic mutation • heart attack • Amish • heart health • scientific study • triglyceride

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