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Cholesterol Drop May Boost Cancer Risk

Study doesn't prove cause-and-effect relationship, docs say

By Heather McPherson,  Newser User

Posted Jul 24, 2007 4:56 PM CDT

(Newser) – Artificially reducing cholesterol to very low levels may slightly increase the risk of cancer, but that doesn't mean heart patients should go off their meds. One extra cancer case occurred in each 1,000 patients using statin drugs in an analysis of 23 different trials, Reuters reports; researchers hastened to caution that that doesn't mean the drugs caused the increase.

The Tufts University study, known as a meta-analysis, compiled statistics on more than 41,000 patients; it zeroed in on those with the lowest LDL ("bad" cholesterol) levels. "You have to be careful," says one statin expert. "People stop taking their statins because they are afraid of cancer and then they die of heart attacks."

A 3D rendering of a cholesterol molecule. Low doses of bad cholesterol in patients correlated with a slight increase in cancer occurrence.
A 3D rendering of a cholesterol molecule. Low doses of "bad" cholesterol in patients correlated with a slight increase in cancer occurrence.   (RedAndr, Wikimedia Commons)
A doctor's advice, and a healthy balanced diet is still the best bet against both heart disease and cancer. You have to be careful about these things, because people stop taking their statins because they are afraid of cancer and then they die of heart attacks, said statin expert Dr....
A doctor's advice, and a healthy balanced diet is still the best bet against both heart disease and cancer. "You have to be careful about these things, because people stop taking their statins because...   (Shutterstock.com)
Statins, the world's best selling drugs, are likely to stay that way as physicians weigh their immediate benefits against long-term side-effects.
Statins, the world's best selling drugs, are likely to stay that way as physicians weigh their immediate benefits against long-term side-effects.   (Shutterstock.com)
Linda Severin, vice president for corporate brands for Kroger, stands next to a display of the new Active Lifestyles milk, a product marketed as cholesterol reducing and fat free, embracing the traditional notion that low cholesterol stems heart disease. A recent study, however, suggests that very low cholesterol may raise...
Linda Severin, vice president for corporate brands for Kroger, stands next to a display of the new Active Lifestyles milk, a product marketed as cholesterol reducing and fat free, embracing the traditional...   (Associated Press)
The Schering-Plough headquarters in Kenilworth, N.J., makers of cholesterol drugs Vytorin and Zetia, seen in this Sept. 6, 2006 file photograph. Despite commercial and medical progress in the battle with cholesterol, new evidence might suggest a downside.(AP Photo/Mel Evans)
The Schering-Plough headquarters in Kenilworth, N.J., makers of cholesterol drugs Vytorin and Zetia, seen in this Sept. 6, 2006 file photograph. Despite commercial and medical progress in the battle with...   (Associated Press)
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