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Sepsis Strikes, Kills Quickly

What starts as infection can turn deadly in a heartbeat

By Paul Stinson,  Newser User

Posted Jan 28, 2009 8:00 AM CST

(Newser) – The quick and seemingly inexplicable death of 20-year-old Brazilian model Mariana Bridi da Costa brought the dangers of sepsis—the body's inflammatory reaction to an infection—into focus, CNN reports. It can start with something as simple as a skin wound or, as in da Costa's case, a urinary tract infection. Most times, the body heals itself, but symptoms of danger include fever, a shift in blood pressure, rapid breathing, and confusion.

Da Costa's case is especially rare because she was young and healthy. The Mayo Clinic sees about 100 such cases a year, with a 75% survival rate. "You can ask, 'Why her?' but really no one knows why her," says one specialist. "It might have something to do with her immune system. It might be about her genetics." Muppets creator Jim Henson died of sepsis, which began as pneumonia, at age 53.

Doctors thought amputating her feet would resolve the situation. When an infection reaches a certain point, this [death] can happen within a matter of hours, said Dr, Kevin Tracey.
Doctors thought amputating her feet would resolve the situation. "When an infection reaches a certain point, this [death] can happen within a matter of hours," said Dr, Kevin Tracey.   (Flickr © MashGet)
Mariana Bridi da Costa at a modeling shoot.
Mariana Bridi da Costa at a modeling shoot.   (Flickr )
Lisa Henson, daughter of Jim Henson and Co-CEO of The Jim Henson Company, unveils a Jim Henson wall sculpture in 2005. The Muppets creator died in 1990 from sepsis.
Lisa Henson, daughter of Jim Henson and Co-CEO of The Jim Henson Company, unveils a Jim Henson wall sculpture in 2005. The Muppets creator died in 1990 from sepsis.   (Michael Buckner/Getty Images)
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