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Down Syndrome Gene Holds Cancer Clue

Downs patients long seen to have lower deadly tumor risk

By Matt Cantor,  Newser Staff

Posted Jun 1, 2009 11:39 AM CDT

(Newser) – Scientists have noticed for years that Down syndrome patients are far less likely to die from solid tumors—and now, scientists in Boston think they know why. Down syndrome patients’ extra chromosome holds a gene that helps cut blood flow to tumors, restricting their growth, the Globe reports. “Individuals with Downs potentially hold a secret that might lead to quite substantial and revolutionary new treatments for cancer,” said a doctor.

The discovery came after years of research and experimentation: While one researcher located the gene on chromosome 21, experts elsewhere were discovering the gene’s ability to stifle blood flow to tumors. Genetic research in mice helped cement the new finding. Cancer treatments of the future could emulate Down syndrome in cancer patients—and some experts say the discovery could lead to a pill aimed at cancer prevention.

A gene on chromosome 21, of which Downs patients have three copies, can fight dangerous tumors.
A gene on chromosome 21, of which Downs patients have three copies, can fight dangerous tumors.   (Shutterstock)
People with Down syndrome have an extra copy of chromosome 21.
People with Down syndrome have an extra copy of chromosome 21.   (Shutterstock)
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COMMENTS
Showing 1 of 1 comment
inky
Jun 1, 2009 7:10 AM CDT
While this is very exciting, I can't help but wonder if there's also a correlation between the shorter life span of Down Syndrome patients; hence fewer years to develop solid tumors.

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