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Moms Can Pass Cancer to Kids In Utero

Mutation makes cancer cells 'invisible' to fetus' immune system

By Harry Kimball,  Newser Staff

Posted Oct 13, 2009 2:05 PM CDT

(Newser) – Mothers pass myriad things to their unborn babies via the placenta, and scientists have found that cancer is among them. Researchers studied the case of a mother who died of leukemia soon after she gave birth, and whose child was diagnosed with cancer months later. Though the baby’s cancer type was different, the Guardian reports, both mother and child contained an identical mutated gene that could not have been inherited.

Therefore, researchers say, the cancer must have passed between mother and child physically. The process was confusing to scientists—the child’s immune system should have detected and destroyed the threat—until they found a mutated gene in both cancers that makes them effectively invisible to the body’s defenses. “The maternal cancer cells did cross the placenta into the developing fetus and succeeded in implanting,” a researcher says. “We are pleased to have resolved this longstanding puzzle.”

A cancer researcher.
A cancer researcher.   (AP Photo)
A 3D ultrasound showing a baby inside the womb.
A 3D ultrasound showing a baby inside the womb.   (Getty Images)
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It appears that in this and, we presume, other cases of mother-to-offspring cancer, the maternal cancer cells did cross the placenta into the developing foetus and succeeded in implanting because they were invisible. - Mel Greaves, University of London

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COMMENTS
Showing 2 of 2 comments
riffran
Oct 13, 2009 8:11 AM CDT
makes ya wonder don't it...especially those who are on medications, or doing things they shouldn't such as illicit drugs or smoking or too much caffeine when pregnant...what the long term effects are
cochiserocks
Oct 13, 2009 7:34 AM CDT
There's so much more to it than nurture vs nature now they've seen how genes can actually alter during our life times. It's all becoming very much about understanding that what you are doing now, has the potential to be passed on - not just the blue print you walked in with, but the blue print you're life has developed. So no pressure there then.

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