NEW YORK (AP) — The latest on developments in financial markets (All times local):

4 p.m.

Health care companies led U.S. indexes slightly higher on Wall Street, and small-company stocks continued their record-setting run.

AbbVie jumped 5 percent Thursday after saying it had reached a deal with a rival that would delay competition for its anti-inflammatory treatment Humira, the biggest-selling drug in the world.

Technology and financial companies also rose. Applied Materials rose 3.6 percent and T. Rowe Price increased 2.3 percent.

The Standard & Poor's 500 rose 3 points, or 0.1 percent, to 2,510.

The Dow Jones industrial average climbed 40 points, or 0.2 percent, to 22,381. The Nasdaq edged up a fraction of a point to 6,453.

The Russell 2000 index of smaller-company stocks rose nearly 4 points, or 0.3 percent, to 1,488.

The S&P 500 and the Russell 2000 closed at record highs.

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11:45 a.m.

Stocks are mixed in midday trading on Wall Street as technology companies decline and health care companies rise.

Apple fell 1 percent Thursday. Drug and medical device maker Abbott Laboratories rose 3.2 percent after regulators approved its new blood glucose monitoring system for diabetes patients.

The Standard & Poor's 500 index was down a fraction of a point at 2,506.

The Dow Jones industrial average rose 33 points, or 0.2 percent, to 22,374. The Nasdaq composite fell 14 points, or 0.2 percent, to 6,439.

Bond prices fell. The yield on the 10-year Treasury note rose to 2.33 percent.

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9:35 a.m.

Stocks are opening slightly lower on Wall Street, led by declines in technology and industrial companies.

Western Digital lost 2.3 percent early Thursday, and Boeing lost 1.4 percent.

Food maker Conagra rose 3.6 percent after reporting a strong quarter, and Abbott Laboratories rose 4.3 percent after winning regulatory approval for a blood glucose monitoring system.

The Standard & Poor's 500 index fell 2 points, or 0.1 percent, to 2,504.

The Dow Jones industrial average lost 30 points, or 0.1 percent, to 22,306. The Nasdaq composite fell 22 points, or 0.4 percent, to 6,430.

Bond prices fell. The yield on the 10-year Treasury note rose to 2.33 percent.