Tom Brady led the New England Patriots back from a three-touchdown deficit as they scored 49 straight points and clinched home-field advantage throughout the AFC playoffs with a 49-21 win over the Buffalo Bills on Sunday.

Brady finished the regular season with the second most yards passing in NFL history, 5,235, after throwing for 338. Drew Brees, who last week broke Dan Marino's record of 5,084 with the Miami Dolphins in 1984, added 389 Sunday for the New Orleans Saints and ended with 5,486.

The Patriots (13-3) finished the season with eight straight wins. But for the second straight game, they fell behind early. They beat the Miami Dolphins 27-24 after trailing 17-0 at halftime then rallied after the Bills (6-10) scored touchdowns on their first three possessions, drawing boos from the home fans.

___

SAINTS 45, PANTHERS 17

At New Orleans, _ Drew Brees threw for 389 yards and five touchdowns as New Orleans set a slew of NFL and club records.

The NFL single-season records set by the Saints (13-3), who head into the playoffs on an eight-game winning streak, included offensive yards with 7,474, team yards passing with 5,347 and first downs with 416.

Brees, who was 28 of 35, finished with a record 468 completions this season, breaking Peyton Manning's 2010 mark of 450. He finished the season completing 71.6 percent of his passes, breaking his own 2009 NFL record 70.6 completion percentage.

Tight end Jimmy Graham had 97 yards receiving, finishing with an NFL record 1,310 for a tight end.

The Panthers finished 6-10.

___

JAGUARS 19, COLTS 13

At Jacksonville, Maurice Jones-Drew ran for a season-high 169 yards, clinching the NFL rushing title and breaking Fred Taylor's single-season franchise record in the Jaguars' victory.

The Jaguars (5-11) became the first AFC South opponent to sweep Indianapolis (2-14) since 2002 and gave outgoing owner Wayne Weaver a victory in his final game.

The Colts may have been the big winners, though. Indianapolis locked up the top pick in April's NFL draft, setting the stage to select Stanford quarterback Andrew Luck.

Indy would have dropped to the No. 2 spot in the draft with a victory in Jacksonville. Instead, owner Jim Irsay will have the choice to draft Luck and give the team a young quarterback to join four-time MVP Peyton Manning.

___

TITANS 23, TEXANS 22

At Houston, Matt Hasselbeck threw two touchdown passes as the Titans kept alive their playoff hopes.

The Titans (9-7) have their first winning record since 2008 in Mike Munchak's first season, but their postseason fate depended on the outcome of later games in Cincinnati, Oakland and Denver. Tennessee got some early help when the Jets lost in Miami.

Houston (10-6) will head into its first postseason on a three-game losing streak. The Texans were locked into the No. 3 seed in the AFC playoffs and coach Gary Kubiak played mostly reserves in the second half.

Rookie starter T.J. Yates left the game after one series with a shoulder injury and was replaced by Jake Delhomme. Kubiak said Yates could have returned if necessary.

The Texans pulled within a point late in the game on a 5-yard TD pass by Delhomme, but failed on a 2-point conversion that would have won it.

____

DOLPHINS 19, JETS 17

At Miami, Mark Sanchez threw three interceptions and the Jets were eliminated from the AFC wild-card playoff race.

Each turnover led to a field goal, and the Jets gave up six third-down conversions during the Dolphins' 21-play, 94-yard drive for their only touchdown.

The Jets (8-8) came into the game needing a win along with losses by three other teams to reach the playoffs. Instead, they finished the season with three consecutive defeats, a big step backward for a team that reached the AFC title game each of the past two years.

The Dolphins (6-10) completed their third consecutive losing season, their longest such stretch since the 1960s.

___

PACKERS 45, LIONS 41

At Green Bay, backup quarterback Matt Flynn threw a touchdown pass to Jermichael Finley with 1:10 left to finish off his record-setting day of 480 yards and six TD passes.

With Aaron Rodgers resting for the playoffs, Flynn set club single-game records for yards passing and touchdowns. It was an ideal afternoon for the Packers (15-1) who got to rest their starting quarterback and several other big-name players without losing momentum.

Flynn barely got the Packers past Matthew Stafford, who threw for 520 yards with five touchdowns and two interceptions. Playoff-bound Detroit (10-6), has lost 21 straight road games to the Packers, including the postseason.

___

BEARS 17, VIKINGS 13

At Minneapolis, Charles Tillman's interception return in the second quarter gave Chicago (8-8) the lead, allowing the Bears to stop their five-game losing streak despite 3 1/2 sacks by Jared Allen.

Allen finished the season with 22 sacks, behind Michael Strahan's NFL mark of 22 1/2 for the Giants in 2001.

Joe Webb relieved Christian Ponder at quarterback for the Vikings (3-13) for the third time in the last month, but the scrambling Webb wasn't able to keep the Vikings from matching the worst record in franchise history.

___

EAGLES 34, REDSKINS 10

At Philadelphia, Michael Vick threw three touchdown passes, including a 62-yarder to DeSean Jackson, as the Eagles closed the season with four straight wins.

The Eagles (8-8) are hoping to carry the momentum from their strong finish into next season. But they can't be satisfied after entering the year with Super Bowl aspirations.

It's the first time since 2007 that Philadelphia didn't qualify for the postseason and just the fourth time in coach Andy Reid's 13 seasons. The Eagles set a franchise record for total yards on offense with 6,386.

The Redskins (5-11) finished in last place in the NFC East for a franchise-worst fourth straight year. It was Mike Shanahan's worst full season in 18 years as a coach.

___

49ERS 34, RAMS 27

At St. Louis, Michael Crabtree caught two touchdown passes, one from kicker David Akers on a perfectly executed trick play, as San Francisco wrapped up the No. 2 playoff seed in the NFC and a first-round bye.

Crabtree and Vernon Davis had big days for a team short of pass catchers and Tarell Brown had a pair of interceptions that led to touchdowns as the 49ers (13-3) beat the Rams (2-14) for the second time the last five games.