The Richest US Cities —and the Salaries They Require San Francisco tops the rich list By Matt Cantor, Newser User Posted Jan 31, 2015 2:47 PM CST 42 comments Comments San Francisco has the most people earning more than $150,000 per year. (Shutterstock) (Newser) – To live comfortably in America's richest city, you'll need $124,561 a year. That's according to a CheatSheet analysis, which defines the wealthiest cities as those with the highest percentage of people making more than $150,000 per year, the Washington Post reports. The analysis also reveals how much you need to make to live comfortably in those cities. The findings are based in part on a 2010 study that says daily "emotional well-being" doesn't climb with income once a household makes at least $75,000; CheatSheet tweaked that figure based on the idea that Phoenix is a fairly "average" city when it comes to income and cost of living. Here are the cities ranked by richness, plus the salaries needed for comfort (which don't necessarily follow the same order): San Francisco: $124,561 San Jose: $115,515 Washington, DC: $108,092 Seattle: $93,634 San Diego: $101,984. Boston: $106,082 Click for the full list.