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Scientists Close In on Antidote to Neurotoxin

Cure would block feared bioweapon that causes paralysis

By Katherine Thompson,  Newser Staff

Posted May 12, 2008 6:11 PM CDT
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(Newser) – Scientists are one step closer to developing an antidote to botulinum, a potentially devastating biological weapon, the BBC reports. Terrorists have tried, so far unsuccessfully, to deploy the neurotoxin, which is also the culprit in botulism and the secret behind Botox. A botulinum vaccine already exists, but the new drug could eventually be used after exposure.

"We anticipate at least four to five years before this can be turned into an approved drug," says the leader of the US research team. But hopes are high for this antidote, which is "about 10 to 15 times better than the best one available so far."

Crystal structure of Botulinum Neurotoxin Serotype A, one of the most potent biological weapons. Scientists are closer to finding an antidote.
Crystal structure of Botulinum Neurotoxin Serotype A, one of the most potent biological weapons. Scientists are closer to finding an antidote.   (Protein Data Bank)
The odorless and colorless botulinum toxin could kill or incapacitate 10% of people within a 500m radius if released.
The odorless and colorless botulinum toxin could kill or incapacitate 10% of people within a 500m radius if released.   (Wnysmart.org)
The molecule in Botox injections, used to smooth out wrinkles, is the same molecule as a deadly nerve toxin that could be used as a terrorist weapon.
The molecule in Botox injections, used to smooth out wrinkles, is the same molecule as a deadly nerve toxin that could be used as a terrorist weapon.   (KRT Photos)
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Toxin can treat neuro disorders, but not headache
US News & World Report

Abstract of the journal article
Journal of Biological Chemistry

 
terrorism • Botox • biological weapons • scientific breakthroughs • botulinum • antidote • neurotoxin

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