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Family History of Breast Cancer Trumps Genes

Incidence among relatives is red flag, even without mutations

By Harry Kimball,  Newser Staff

Posted Nov 17, 2008 2:40 PM CST

(Newser) – Women with family history of breast cancer are at elevated risk even if they don’t have a proven genetic indicator, HealthDay reports. Specific mutations in the BRCA gene correlate with an 80% lifetime risk of developing breast cancer; women in a new study who had a family history of the disease, but not that marker, had a 40% chance of developing it. The average woman has a 10% lifetime risk of developing breast cancer.

Another genetic abnormality, apart from the BRCA mutation, could be responsible for the findings, the study's author said. The Canadian researchers tracked 1,500 women from 365 families with a history of breast cancer. "Now when we see families such as this, we will be able to offer better advice about their actual risk," the lead researcher told WebMD.

Mammogram images.
Mammogram images.   (AP Photo)
A standard mammogram, left, and  molecular breast imaging (MBI) from a study performed on a 45-year-old patient in the clinic's screening of women with dense breasts.
A standard mammogram, left, and molecular breast imaging (MBI) from a study performed on a 45-year-old patient in the clinic's screening of women with dense breasts.   (AP Photo)
A doctor uses special glasses to review breast images on a planar stereo display workstation.
A doctor uses special glasses to review breast images on a planar stereo display workstation.   (AP Photo)
A right breast MRI.
A right breast MRI.   (AP Photo)
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