Working Mouse Sperm Created From Stem Cells

Step could someday lead to treatment for infertile men
By Newser Editors and Wire Services
Posted Feb 25, 2016 2:22 PM CST
Working Mouse Sperm Created From Stem Cells
This photo provided by Xiao-Yang Zhao of the Southern Medical University in Guangzhou, China on Thursday, Feb. 25, 2016, shows one of the offspring produced with rudimentary mouse sperm derived from stem cells.   (Uncredited)

Scientists have produced rudimentary mouse sperm from stem cells in the laboratory, a step that may lead to a treatment for infertile men. If the technique pans out in people, doctors might someday be able to turn skin cells from a man into sperm that can pass along his DNA to his offspring, the AP reports. But experts warned that the technology would have to overcome some hurdles first. The mouse work is reported by Chinese scientists in an article released Thursday by the journal Cell Stem Cell. The technique is now being tested in monkeys, a senior author said. Qi Zhou of the Chinese Academy of Sciences in Beijing added in an email that the research has "a long way to go" before it could be used for infertile men.

The scientists began with mouse embryonic stem cells, which are found in embryos and can develop into any kind of cell in the body. In the lab these cells were exposed to chemicals to nudge them toward becoming sperm. While previous research has also generated sperm precursors in this way, these precursors then had to be transplanted into the testicles of mice to develop further. The new technique is an advance, experts said, because it eliminates the need for transplants. Instead, the researchers put the sperm precursors in a lab dish containing testicle cells. Although the precursors never became fully mature sperm, they developed far enough to fertilize eggs. They were injected into 379 eggs; nine baby mice resulted. Click for more on how it could work with humans. (More infertility stories.)

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