After 23 years of The Oprah Winfrey Show, the queen of talk has racked up quite a few memorable moments. In the wake of news that she's going to end the show in 2011, E! runs down the top nine, including Tom Cruise’s crazy couch dance, her car giveaway, James Frey, her Michael Jackson interview, and Sarah Palin’s sitdown. Check out a few of the clips in the gallery.
(Read more Oprah Winfrey stories.)